Journal article
Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: A systematic review and individual participant data meta-analysis
C Ovadia, J Sajous, PT Seed, K Patel, NJ Williamson, G Attilakos, F Azzaroli, Y Bacq, L Batsry, K Broom, R Brun-Furrer, L Bull, J Chambers, Y Cui, M Ding, PH Dixon, MC Estiú, FW Gardiner, V Geenes, M Grymowicz Show all
Obstetrical and Gynecological Survey | Published : 2021
Open access
Abstract
Background: Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes. Methods: In this systematic review and individual participant data meta-analysis, we searched PubMed, Web of Science, Embase, MEDLINE, CINAHL, Global Health, MIDIRS, and Cochrane without language restrictions for relevant articles published between database inception, and Jan 1, 2020, using search terms referencing intrahepatic cholestasis of pregnancy, ursodeoxycholic acid, a..
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Awarded by National Institute for Health Research
Funding Acknowledgements
This study was funded by Tommy's (registered charity number 1060508), the Wellcome Trust (092993/Z/10/Z), ICP Support, and the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust and King's College London (IS-BRC-1215-20006). CW is supported by a NIHR Senior Investigator Award. PTS is partly funded by NIHR Collaboration for Leadership in Applied Health Research and Care South London. The views expressed in this Article are those of the authors and not necessarily those of the National Health Service, the NIHR, or the Department of Health. We thank Ge Han for translating Chinese language manuscripts.