Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease
Camilla Bertuzzo Veiga, Erin M Lawrence, Andrew J Murphy, Marco J Herold, Dragana Dragoljevic
CANCERS | MDPI | Published : 2021
The development of myelodysplasia syndromes (MDS) is multiphasic and can be driven by a plethora of genetic mutations and/or abnormalities. MDS is characterized by a hematopoietic differentiation block, evidenced by increased immature hematopoietic cells, termed blast cells and decreased mature circulating leukocytes in at least one lineage (i.e., cytopenia). Clonal hematopoiesis of indeterminate potential (CHIP) is a recently described phenomenon preceding MDS development that is driven by somatic mutations in hemopoietic stem cells (HSCs). These mutant HSCs have a competitive advantage over healthy cells, resulting in an expansion of these clonal mutated leukocytes. In this review, we disc..View full abstract
Awarded by Australian National Health and Medical Research Council NHMRC
A.J.M is supported by a Centenary Award from CSL. C.B.V is supported by an GR scholarship from The University of Melbourne and a Bright Sparks award from the Baker Heart and Diabetes Institute. M.J.H is supported by a fellowship from the Australian National Health and Medical Research Council NHMRC (1156095).