Journal article

Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease

Camilla Bertuzzo Veiga, Erin M Lawrence, Andrew J Murphy, Marco J Herold, Dragana Dragoljevic

CANCERS | MDPI | Published : 2021

Abstract

The development of myelodysplasia syndromes (MDS) is multiphasic and can be driven by a plethora of genetic mutations and/or abnormalities. MDS is characterized by a hematopoietic differentiation block, evidenced by increased immature hematopoietic cells, termed blast cells and decreased mature circulating leukocytes in at least one lineage (i.e., cytopenia). Clonal hematopoiesis of indeterminate potential (CHIP) is a recently described phenomenon preceding MDS development that is driven by somatic mutations in hemopoietic stem cells (HSCs). These mutant HSCs have a competitive advantage over healthy cells, resulting in an expansion of these clonal mutated leukocytes. In this review, we disc..

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University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council NHMRC


Funding Acknowledgements

A.J.M is supported by a Centenary Award from CSL. C.B.V is supported by an GR scholarship from The University of Melbourne and a Bright Sparks award from the Baker Heart and Diabetes Institute. M.J.H is supported by a fellowship from the Australian National Health and Medical Research Council NHMRC (1156095).