Journal article

Treponema pallidum detection in lesion and non-lesion sites in men who have sex with men with early syphilis: a prospective, cross-sectional study

Janet M Towns, David E Leslie, Ian Denham, Rebecca Wigan, Francesca Azzato, Deborah A Williamson, Darren Lee, Eric PF Chow, Christopher K Fairley, Stephen R Graves, Lei Zhang, Marcus Y Chen

LANCET INFECTIOUS DISEASES | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: Syphilis transmission is increasing, and precisely how Treponema pallidum is transmitted sexually from person to person is unclear. We aimed to determine the frequency of T pallidum shedding from potentially asymptomatic sites and the stage of infection at which shedding is most frequent in men who have sex with men (MSM), who have been disproportionately affected by syphilis. METHODS: We did a prospective, cross-sectional study in MSM recruited from Melbourne Sexual Health Centre (Melbourne, VIC, Australia). Men were eligible if they were aged 18 years or older, reported sex with men during the past 12 months, and had laboratory confirmed primary, secondary, or early latent syph..

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