How qPCR complements the WHO roadmap (2021-2030) for soil-transmitted helminths
Marina Papaiakovou, Timothy J Littlewood, Robin B Gasser, Roy M Anderson
TRENDS IN PARASITOLOGY | ELSEVIER SCI LTD | Published : 2021
Complementing the launch of the World Health Organization (WHO) roadmap (2021-2030) we explore key elements needing attention before recruitment of qPCR as the main diagnostics tool to confirm reduction or elimination of soil-transmitted helminth (STH) transmission in both control and elimination programmes. Given the performance limitations of conventional methods, a proposed harmonised qPCR will provide a diagnostic tool, with the sensitivity and specificity required to monitor low-intensity infections, following mass drug administration (MDA). Technical and logistical challenges associated with introducing qPCR as a stand-alone tool are highlighted, and a decision-making scheme on how qPC..View full abstract
Awarded by Children's Investment Fund Foundation (CIFF)
R.M.A. and M.P. would like to thank the Children's Investment Fund Foundation (CIFF) for their continued support (grant reference number 1902-03568; the funder had no role in writing the manuscript). R.M.A., D.T.J.L., and M.P. would like to thank Justine Marshall, manager of LCNTDR for logistical support. R.B.G.'s research programme is supported mainly by the Australian Research Council (ARC), Yourgene Health Singapore, and Melbourne Water Corporation.