Journal article
Stealth nanorodsviathe aqueous living crystallisation-driven self-assembly of poly(2-oxazoline)s
JR Finnegan, EH Pilkington, K Alt, MA Rahim, SJ Kent, TP Davis, K Kempe
Chemical Science | ROYAL SOC CHEMISTRY | Published : 2021
DOI: 10.1039/d1sc00938a
Abstract
The morphology of nanomaterials critically influences their biological interactions. However, there is currently a lack of robust methods for preparing non-spherical particles from biocompatible materials. Here, we combine ‘living’ crystallisation-driven self-assembly (CDSA), a seeded growth method that enables the preparation of rod-like polymer nanoparticles, with poly(2-oxazoline)s (POx), a polymer class that exhibits ‘stealth’ behaviour and excellent biocompatibility. For the first time, the ‘living’ CDSA process was carried out in pure water, resulting in POx nanorods with lengths ranging from ∼60 to 635 nm.In vitroandin vivostudy revealed low immune cell association and encouraging blo..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
K. K. gratefully acknowledges the award of an ARC Future Fellowship (FT190100572) from the Australian Research Council (ARC). K. A. is supported by the National Health and Medical Research Council of Australia (Career Development Fellowship GNT1140465). This work was -in part -carried out within the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). We would like to thank the Bio21 Advanced Microscopy Facility (University of Melbourne) and Prof. Patrick Sexton (Monash University) for access to their electron microscopy facilities. Finally, the authors acknowledge the use of the facilities and the assistance of Dr Jisheng Ma at the Monash X-ray Platform, as well as the support provided to this project by the HMS Trust Laboratory, based at the Monash Institute of Pharmaceutical Sciences.