Journal article

Association of Structural Magnetic Resonance Imaging Measures With Psychosis Onset in Individuals at Clinical High Risk for Developing Psychosis An ENIGMA Working Group Mega-analysis

Maria Jalbrzikowski, Rebecca A Hayes, Stephen J Wood, Dorte Nordholm, Juan H Zhou, Paolo Fusar-Poli, Peter J Uhlhaas, Tsutomu Takahashi, Gisela Sugranyes, Yoo Bin Kwak, Daniel H Mathalon, Naoyuki Katagiri, Christine I Hooker, Lukasz Smigielski, Tiziano Colibazzi, Esther Via, Jinsong Tang, Shinsuke Koike, Paul E Rasser, Chantal Michel Show all

JAMA PSYCHIATRY | AMER MEDICAL ASSOC | Published : 2021

Abstract

Importance: The ENIGMA clinical high risk (CHR) for psychosis initiative, the largest pooled neuroimaging sample of individuals at CHR to date, aims to discover robust neurobiological markers of psychosis risk. Objective: To investigate baseline structural neuroimaging differences between individuals at CHR and healthy controls as well as between participants at CHR who later developed a psychotic disorder (CHR-PS+) and those who did not (CHR-PS-). Design, Setting, and Participants: In this case-control study, baseline T1-weighted magnetic resonance imaging (MRI) data were pooled from 31 international sites participating in the ENIGMA Clinical High Risk for Psychosis Working Group. CHR statu..

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Grants

Awarded by National Institute of Mental Health


Awarded by National Health and Medical Research Council


Awarded by Lundbeck Foundation


Awarded by UK Medical Research Council


Awarded by Brain and Behavior Research Foundation


Awarded by European Regional Development Fund


Awarded by Government of Catalonia


Awarded by National Institutes of Health


Awarded by National Natural Science Foundation of China


Awarded by Japan Agency for Medical Research and Development


Awarded by Japan Society for the Promotion of Science KAKENHI


Awarded by Russian Foundation for Basic Research


Awarded by Consejo Nacional de Ciencia y Tecnologia


Awarded by Research Council of Norway


Awarded by South-Eastern Norway Regional Health Authority


Awarded by Instituto de Salud Carlos III


Awarded by National Medical Research Council Translational and Clinical Research Flagship Programme


Awarded by National Medical Research Council


Awarded by National Research Foundation of Korea


Awarded by Australian National Health and Medical Research Council


Awarded by Zurich Program for Sustainable Development of Mental Health Services


Awarded by National Health and Medical Research Council of Australia


Awarded by Maryland Department of Health and Mental Hygiene, Behavioral Health Administration through the Maryland Center of Excellence on Early Intervention Program


Awarded by European Union


Funding Acknowledgements

Dr Jalbrzikowski has received grant K01 MH112774 from the National Institute of Mental Health. Dr Hayes has received grants from the University of Pittsburgh Medical Center. Drs Wood, Amminger, Bartholomeusz, McGorry, Nelson, and Yung have received funding from the Colonial Foundation. DrsWood, McGorry, and Yung have received grant 566529 from the National Health and Medical Research Council. DrWood has received Clinical Career Development Award 359223 from the National Health and Medical Research Council. Dr Nordholm has received grants R25-A2701 and R287-2018-1485 from the Lundbeck Foundation and grants from the Mental Health Services Capital Region of Denmark. Dr Zhou has received grants from the Yong Loo Lin School of Medicine at the National University of Singapore. Drs Fusar-Poli, Allen, and McGuire and have received grant UK G0700995 from the UK Medical Research Council. Dr Uhlhaas has received grant MR/L011689/1 from the UK Medical Research Council. Dr Sugranyes has received Young Investigator Award grant 26731 from the Brain and Behavior Research Foundation, grants from the Spanish I+D+I state program, grants from the ISCIII-Subdireccion General de Evaluacion, grant PI18/00976 from the European Regional Development Fund, grant SLT006/17/00362 from the Government of Catalonia (Programa PERIS Salut Mental), grants from the Alicia Koplowitz Foundation, and grants from the Fundacio Clinic Recerca Biomedica (Ajut a la Recerca Pons Bartran). Dr Mathalon has received grants from the Brain and Behavior Research Foundation and grant R01 MH076989 from the National Institute of Mental Health. Dr Hooker was supported by grant R01 MH105246 from the National Institutes of Health. Dr Colibazzi has received grants 5T32MH15144 and K23 MH85063 from the National Institute of Mental Health as well as grants from the Brain and Behavior Research Foundation, Sackler Institute, Herbert Irving Scholar Award, and Columbia University Bodini Fellowship. Dr Tang has received grant 81871057 from the National Natural Science Foundation of China. Drs Koike and Kasai have received grants JP20dm0307004 and JP20dm0207069 from the Japan Agency for Medical Research and Development. Dr Koike has received grant JP18K07550 from the Japan Society for the Promotion of Science KAKENHI. Dr Lebedeva and Mr Tomyshev were supported by grant 20-013-00748 from the Russian Foundation for Basic Research. Dr de la Fuente-Sandoval was supported by grants 182279 and 261895 from the Consejo Nacional de Ciencia y Tecnologia, grants from CONACYT's Sistema Nacional de Investigadores, and grant R21 MH117434 from the National Institutes of Health. DrWaltz has received grant 5R01MH115031 from the National Institute of Mental Health. Dr Mizrahi has received grants R01MH100043 and R01MH113564 from the National Institute of Mental Health and grants from the Brain and Behavior Research Foundation and Canadian Institutes of Health Research. Dr Corcoran has received grant R01 MH107558 from the National Institutes of Health. Dr Tamnes has received grants 288083 and 223273 from the Research Council of Norway and grant 2019069 from the South-Eastern Norway Regional Health Authority. Dr Amminger has received Senior Research Fellowship grant 1080963 from the National Health and Medical Research Council. Dr Andreassen has received grants 223273 and 283798 from the Research Council of Norway as well as grants from K. G. Jebsen Stiftelsen and UiO: Life Science. Ms Atkinson has received grants from the University of Edinburgh.Dr Baeza has received grants INT19/00021, PI11/1349, PI15/0444, and PI180242 from the Instituto de Salud Carlos III. Ms Baldwin has received funding from the National Institute for Health Research Maudsley Biomedical Research Centre studentship. Dr Borgwardt has received grants from the SYNSCHIZ project under the ERA-NET Horizon 2020 program. Drs Chee and Lee received grant NMRC/TCR/003/2008 from the National Medical Research Council Translational and Clinical Research Flagship Programme. Dr Chee has received grant NMRC/STaR/0015/2013 from the National Medical Research Council. Dr Cropley has received investigator grant 1177370 and project grant 1065742 from the National Health and Medical Research Council. Dr Dolz has received grants PI11/02684 and PI15/00509 from the Instituto de Salud Carlos III and a grant from the Alicia Koplowitz Foundation. Dr Louise Glenthoj was supported by the Tryg Foundation and Danish Research Council. Dr Birte Glenthoj was supported by the Lundbeck Foundation Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research. Mr Harris has received grants from the Wellcome Trust. Dr Kasai has received grants JP18dm0207004 and JP20dm0307001 from the Japan Agency for Medical Research and Development and grants JP16H06395, JP16H06399, JP16K21720, JP16H06280, and 20H03596 from the Japan Society for the Promotion of Science KAKENHI. Dr Klaunig has received grants from the National Institute of Mental Health. Dr Kwon has received grant 2017M3C7A1029610 from the National Research Foundation of Korea. Dr Lin was supported by grant 1148793 from the Australian National Health and Medical Research Council. Dr Loewy has received grants K23MH086618 and R01MH081051 from the National Institute of Mental Health. Drs McGorry and Yung have received grant 350241 from the National Health and Medical Research Council. Dr Nelson has received Career Development Fellowship grant 1027532, Senior Research Fellowship grant 1137687, and project grant 1027741 from the National Health and Medical Research Council. Dr Oppedal has received postdoctoral scholarship grant 912152 from theWestern Norway Regional Health Authority. Dr Pantelis has received Senior Principal Research Fellowship grant 1105825 and L3 Investigator grant 1196508 from the National Health and Medical Research Council as well as Distinguished Investigator Award 18722 from the Brain and Behavior Research Foundation. Dr Rossler has received grants from the Zurich Program for Sustainable Development of Mental Health Services. Dr Salisbury has received grant R01 MH113533 from the National Institute of Mental Health. Dr Sasabayashi has received grant JP18K15509 from the Japan Society for the Promotion of Science KAKENHI. Dr Schall has received grant 569259 from the National Health and Medical Research Council of Australia. Dr Schiffman has received grants from the Maryland Department of Health and Mental Hygiene, Behavioral Health Administration through the Maryland Center of Excellence on Early Intervention Program, grant 14-13717G/M00B4400241 from the Office of Procurement and Support Services, and grant R01MH112612 from the National Institute of Mental Health. Dr Suzuki has received grant JP20H03598 from the Japan Society for the Promotion of Science KAKENHI and grant JP19dk0307069s0203 from the Japan Agency for Medical Research and Development. Ms Tor has received grants PI11/02684 and PI15/00509 from the Instituto de Salud Carlos III.Dr Westlye has received grant 300767 from the Research Council of Norway, grant 2019101 from the South-Eastern Norway Regional Health Authority, and European Union's Horizon 2020 Research and Innovation Program grant 802998 from the European Research Council. Dr Yung has received Principal Research Fellowship grant GNT1136829 from the National Health and Medical Research Council and Senior Research Fellowship grant 566593 from the National Health and Medical Research Council. Dr Turner has received grant 5R01MH094524 from the National Institutes of Health.