Journal article

Late/post-term decidual basalis-derived mesenchymal stem/stromal cells show evidence of advanced ageing and downregulation of microRNA-516b-5p

Ramin Khanabdali, Shixuan Zheng, Phillip E Melton, Harry M Georgiou, Eric Moses, Shaun P Brennecke, Bill Kalionis

PLACENTA | W B SAUNDERS CO LTD | Published : 2021


INTRODUCTION: The placenta is a short-lived organ, yet it shows signs of progressive ageing in the third trimester. Studies of ageing chorionic placental tissue have recently flourished, providing evidence of advanced ageing of tissues in the late/post-term (L/PT) period of gestation. However, ageing of the maternal aspect of the maternal-fetal interface, specifically the decidua basalis, is poorly understood. Here, we investigated whether the L/PT period was associated with advanced ageing and exhaustion of important decidua basalis mesenchymal stem/stromal cells (DMSCs) functions. METHODS: In this study, DMSCs were isolated and characterised from early term (ET) and L/PT placental tissue a..

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Funding Acknowledgements

The authors would like to thank the research midwifes for collecting the placental samples. The authors would also like to thank Australian genome research facility (AGRF) for their sequencing and Dr Mark Pertile (Victorian Clinical Genetics Services) for FISH analysis. We wish to acknowledge the Trevor Basil Kilvington Bequest, Grant-in-Aid for Preeclampsia Research, The University of Melbourne for partial funding of this work.