Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications
Mohit Kumar Jolly, Ryan J Murphy, Sugandha Bhatia, Holly J Whitfield, Andrew Redfern, Melissa J Davis, Erik W Thompson
CELLS TISSUES ORGANS | KARGER | Published : 2021
The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.
Awarded by SPARC grant - MHRD, Government of India
Awarded by National Breast Cancer Foundation
Awarded by Cancer Council Victoria
M.K.J. and E.W.T. were supported by a SPARC grant awarded by MHRD, Government of India (SPARC/2018-2019/P303/SL). M.J.D. and E.W.T. received foundational support from the National Breast Cancer Foundation (CG-10-04). M.J.D. is funded by Cancer Council Victoria APP1187825, Cure Brain Cancer and the National Breast Cancer Foundation (CBCNBCF-19-009), and the Betty Smyth Centenary Fellowship in Bioinformatics. S.B. was supported by a QUT Postgraduate Research Award scholarship. The Translational Research Institute is funded by a grant from the Australian Government.