Journal article

Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications

Mohit Kumar Jolly, Ryan J Murphy, Sugandha Bhatia, Holly J Whitfield, Andrew Redfern, Melissa J Davis, Erik W Thompson

CELLS TISSUES ORGANS | KARGER | Published : 2021

Abstract

The epithelial-mesenchymal (E/M) hybrid state has emerged as an important mediator of elements of cancer progression, facilitated by epithelial mesenchymal plasticity (EMP). We review here evidence for the presence, prognostic significance, and therapeutic potential of the E/M hybrid state in carcinoma. We further assess modelling predictions and validation studies to demonstrate stabilised E/M hybrid states along the spectrum of EMP, as well as computational approaches for characterising and quantifying EMP phenotypes, with particular attention to the emerging realm of single-cell approaches through RNA sequencing and protein-based techniques.

University of Melbourne Researchers

Grants

Awarded by SPARC grant - MHRD, Government of India


Awarded by National Breast Cancer Foundation


Awarded by Cancer Council Victoria


Funding Acknowledgements

M.K.J. and E.W.T. were supported by a SPARC grant awarded by MHRD, Government of India (SPARC/2018-2019/P303/SL). M.J.D. and E.W.T. received foundational support from the National Breast Cancer Foundation (CG-10-04). M.J.D. is funded by Cancer Council Victoria APP1187825, Cure Brain Cancer and the National Breast Cancer Foundation (CBCNBCF-19-009), and the Betty Smyth Centenary Fellowship in Bioinformatics. S.B. was supported by a QUT Postgraduate Research Award scholarship. The Translational Research Institute is funded by a grant from the Australian Government.