Journal article

Cognition-immune interactions between executive function and working memory, tumour necrosis factor-alpha (TNF-alpha) and soluble TNF receptors (sTNFR1 and sTNFR2) in bipolar disorder

Robson Zazula, Seetal Dodd, Olivia M Dean, Michael Berk, Chiara C Bortolasci, Waldiceu A Verri Jr, Heber O Vargas, Sandra O Nunes

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | TAYLOR & FRANCIS LTD | Published : 2021

Abstract

OBJECTIVES: This study examined cognition-immune interactions, specifically executive function, working memory, peripheral levels of tumour necrosis factor-alpha (TNF-α), and soluble tumour necrosis factor receptors-1 and -2 (sTNFR1 and 2) levels in bipolar disorder (BD) patients in comparison with controls. METHODS: Thirty-one BD participants and twenty-seven controls participated in the study. The neurocognitive assessment was performed through three of CogState Research BatteryTM tasks for executive function and working memory. Plasma levels of TNF-α, sTNFR1, and sTNFR2 were measured after overnight fasting. Sociodemographic data and symptom severity of depression and mania were assessed...

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University of Melbourne Researchers

Grants

Awarded by CAPES


Awarded by UNILA (PRPPG UNILA)


Awarded by NHMRC R.D. Wright Biomedical Research Fellowship


Awarded by Brazilian National Council for Scientific and Technological Development (CNPq)


Awarded by National Health and Medical Research Council (NHMRC)


Funding Acknowledgements

RZ received a scholarship from CAPES (PDSE - 1.187966/2018-01) and financial support from UNILA (PRPPG UNILA no 109/2017). OMD is supported by a NHMRC R.D. Wright Biomedical Research Fellowship (APP1145634). MB is supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072). CB is supported by an Alfred Deakin Postdoctoral Research Fellowship. WAVJ receives a Senior Research Fellowship from Brazilian National Council for Scientific and Technological Development (CNPq) (307186/2017-2). SOVN received financial support from CNPq (CNPq 470344/2013-0 and CNPq 465928/2014-5).