Journal article

CCL17-expressing dendritic cells in the intestine are preferentially infected by Salmonella but CCL17 plays a redundant role in systemic dissemination

Anna B Erazo, Nancy Wang, Lena Standke, Adrian D Semeniuk, Lorenz Fuelle, Sevgi C Cengiz, Manja Thiem, Heike Weighardt, Richard A Strugnell, Irmgard Foerster

IMMUNITY INFLAMMATION AND DISEASE | WILEY | Published : 2021

Abstract

INTRODUCTION: Salmonella spp. are a recognized and global cause of serious health issues from gastroenteritis to invasive disease. The mouse model of human typhoid fever, which uses Salmonella enterica serovar Typhimurium (STM) in susceptible mouse strains, has revealed that the bacteria gain access to extraintestinal tissues from the gastrointestinal tract to cause severe systemic disease. Previous analysis of the immune responses against Salmonella spp. revealed the crucial role played by dendritic cells (DCs) in carrying STM from the intestinal mucosa to the mesenteric lymph nodes (mLNs), a key site for antigen presentation and T cell activation. In this study, we investigated the influen..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by Deutscher Akademischer Austauschdienst


Awarded by Jurgen Manchot Stiftung


Awarded by Deutsche Forschungsgemeinschaft


Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: 1092262; Australian Research Council, Grant/Award Number: Discovery Project DP200103110; Melbourne Research, University of Melbourne, Grant/Award Number: Scholarship to A.D.S.; Deutscher Akademischer Austauschdienst, Grant/Award Numbers: 57388494, 57511500; Jurgen Manchot Stiftung, Grant/Award Number: MOI; Deutsche Forschungsgemeinschaft, Grant/Award Number: IRTG2168