Improved HIV-positive infant survival is correlated with high levels of HIV-specific ADCC activity in multiple cohorts
Zak A Yaffe, Nicole E Naiman, Jennifer Slyker, Bruce D Wines, Barbra A Richardson, P Mark Hogarth, Rose Bosire, Carey Farquhar, Dorothy Mbori Ngacha, Ruth Nduati, Grace John-Stewart, Julie Overbaugh
CELL REPORTS MEDICINE | ELSEVIER | Published : 2021
Defining immune responses that protect humans against diverse HIV strains has been elusive. Studying correlates of protection from mother-to-child transmission provides a benchmark for HIV vaccine protection because passively transferred HIV antibodies are present during infant exposure to HIV through breast milk. A previous study by our group illustrated that passively acquired antibody-dependent cellular cytotoxicity (ADCC) activity is associated with improved infant survival whereas neutralization is not. Here, we show, in another cohort and with two effector measures, that passively acquired ADCC antibodies correlate with infant survival. In combined analyses of data from both cohorts, t..View full abstract
Awarded by NIH
Awarded by Flow Cytometry shared resource of the Fred Hutch/University of Washington Cancer Consortium
We thank the participants and staff of the NBT and CTL cohorts. We thank Vrasha Chohan for initial help with the dimeric FcgR ELISA. This work was supported by NIH R01 HD103571 (to J.O.), training award T32 AI083203 (to Z.A.Y.), NIH F30AI136636 (to N.E.N.), and NHMRC project funding (to B.D.W. and P.M.H.). This research was also supported by the Flow Cytometry shared resource of the Fred Hutch/University of Washington Cancer Consortium (P30 CA015704). The graphical abstract was generated with BioRender.