Journal article

Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group

Maria Gloria Rossetti, Scott Mackey, Praveetha Patalay, Nicholas B Allen, Albert Batalla, Marcella Bellani, Yann Chye, Patricia Conrod, Janna Cousijn, Hugh Garavan, Anna E Goudriaan, Robert Hester, Rocio Martin-Santos, Nadia Solowij, Chao Suo, Paul M Thompson, Murat Yucel, Paolo Brambilla, Valentina Lorenzetti

TRANSLATIONAL PSYCHIATRY | SPRINGERNATURE | Published : 2021

Abstract

Males and females show different patterns of cannabis use and related psychosocial outcomes. However, the neuroanatomical substrates underlying such differences are poorly understood. The aim of this study was to map sex differences in the neurobiology (as indexed by brain volumes) of dependent and recreational cannabis use. We compared the volume of a priori regions of interest (i.e., amygdala, hippocampus, nucleus accumbens, insula, orbitofrontal cortex (OFC), anterior cingulate cortex and cerebellum) between 129 regular cannabis users (of whom 70 were recreational users and 59 cannabis dependent) and 114 controls recruited from the ENIGMA Addiction Working Group, accounting for intracrani..

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Grants

Awarded by NIH


Awarded by ZonMW from NWO


Awarded by Cannabis Prospective study from ZonMW from NWO


Awarded by Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council


Awarded by Australian Research Council


Awarded by National Health and Medical Research Council Fellowship


Funding Acknowledgements

P.M.T. was funded in part by NIH grants U54 EB020403, R01MH116147, and R56 AG058854.Data collection: A.E.G. received funding from ZonMW grant 91676084 from NWO. A.E.G. and J.C. received funding for the Cannabis Prospective study from ZonMW grant 31180002 from NWO. N.S. received funding from the Clive and Vera Ramaciotti Foundation for Biomedical Research National and Health and Medical Research Council Project grant 459111 and was supported by Australian Research Council Future Fellowship FT110100752. M.Y. was supported by National Health and Medical Research Council Fellowship 1117188 and the David Winston Turner Endowment Fund. V.L. was supported by The Australian Catholic University through a competitive scheme.