Effects of antipsychotic drugs and potassium channel modulators on spectral properties of local field potentials in mouse hippocampus and pre-frontal cortex
Dechuan Sun, Mojtaba Kermani, Matthew Hudson, Xin He, Ranjith Rajasekharan Unnithan, Chris French
NEUROPHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021
Local field potentials (LFPs) recorded intracranially display a range of location-specific oscillatory spectra which have been related to cognitive processes. Although the mechanisms producing LFPs are not completely understood, it is likely that voltage-gated ion channels which produce action potentials and patterned discharges play a significant role. It is also known that antipsychotic drugs (APDs) affect LFP spectra and a direct inhibitory effect on voltage-gated potassium channels has been reported. Additionally, voltage-gated potassium channels have been implicated in the pathophysiology of schizophrenia, a disorder for which APDs are primary therapies. In this study we sought to: i) b..View full abstract
Awarded by Australian Research Council
This work was supported by grants from the Australian Research Council under Discovery Project (DP170100363) and the Royal Melbourne Hospital Neuroscience Foundation.