Journal article

Kidney age-chronological age difference (KCD) score provides an age-adapted measure of kidney function

Duncan J Campbell, Jennifer M Coller, Fei Fei Gong, Michele McGrady, Umberto Boffa, Louise Shiel, Danny Liew, Simon Stewart, Alice J Owen, Henry Krum, Christopher M Reid, David L Prior

BMC NEPHROLOGY | BMC | Published : 2021

Abstract

BACKGROUND: Given the age-related decline in glomerular filtration rate (GFR) in healthy individuals, we examined the association of all-cause death or cardiovascular event with the Kidney age - Chronological age Difference (KCD) score, whereby an individual's kidney age is estimated from their estimated GFR (eGFR) and the age-dependent eGFR decline reported for healthy living potential kidney donors. METHODS: We examined the association between death or cardiovascular event and KCD score, age-dependent stepped eGFR criteria (eGFRstep), and eGFR < 60 ml/min/1.73 m2 (eGFR60) in a community-based high cardiovascular risk cohort of 3837 individuals aged ≥60 (median 70, interquartile range 65, 7..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart Foundation of Australia


Awarded by Diabetes Australia Research Trust


Funding Acknowledgements

This research was supported by Bupa Australia, with subsequent support from the National Health and Medical Research Council of Australia (GTN0559010, GTN1044619, GTN1092642, GTN0395508 to D.J.C., GTN1045862, GTN1136372 to C.M.R., GTN1041796 to S.S., GTN0620241 to J.M.C., GNT0519456 to M.M.), the National Heart Foundation of Australia (G 07 M 3198, 102956), the Diabetes Australia Research Trust (Y15G-CAMD), The University of Melbourne, St. Vincent's Hospital Melbourne, St. Vincent's Institute of Medical Research, and the Victorian Government's Operational Infrastructure Support Program.