Early treatment delays long-term disability accrual in RRMS: Results from the BMSD network
Pietro Iaffaldano, Giuseppe Lucisano, Helmut Butzkueven, Jan Hillert, Robert Hyde, Nils Koch-Henriksen, Melinda Magyari, Fabio Pellegrini, Tim Spelman, Per Soelberg Sorensen, Sandra Vukusic, Maria Trojano
MULTIPLE SCLEROSIS JOURNAL | SAGE PUBLICATIONS LTD | Published : 2021
BACKGROUND: The optimal timing of treatment starts for achieving the best control on the long-term disability accumulation in multiple sclerosis (MS) is still to be defined. OBJECTIVE: The aim of this study was to estimate the optimal time to start disease-modifying therapies (DMTs) to prevent the long-term disability accumulation in MS, using a pooled dataset from the Big Multiple Sclerosis Data (BMSD) network. METHODS: Multivariable Cox regression models adjusted for the time to first treatment start from disease onset (in quintiles) were used. To mitigate the impact of potential biases, a set of pairwise propensity score (PS)-matched analyses were performed. The first quintile, including ..View full abstract
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported by Biogen International (Zug, Switzerland) on the basis of a Sponsored Research Agreement in place with the Big MS Data Network.