First Description of the Composition and the Functional Capabilities of the Skin Microbial Community Accompanying Severe Scabies Infestation in Humans
Charlotte Bernigaud, Martha Zakrzewski, Sara Taylor, Pearl M Swe, Anthony T Papenfuss, Kadaba S Sriprakash, Deborah Holt, Olivier Chosidow, Bart J Currie, Katja Fischer
MICROORGANISMS | MDPI | Published : 2021
Epidemiological studies link Sarcoptes scabiei infection and impetigo. Scabies mites can promote Streptococcus pyogenes (Group A Streptococcus) and Staphylococcus aureus infections by breaching the skin barrier and excreting molecules that inhibit host innate immune responses. However, little is known about the composition and the function of the scabies-associated microbiota. Here, high-throughput whole-metagenome sequencing was used to explore the scabies-associated microbiome. Scabies mites including their immediate microenvironments were isolated from two patients with severe scabies in Northern Australia. Two ~45-50 million paired-end reads Illumina libraries were generated of which ~2 ..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by Australian NHMRC
C.B. was supported by a PhD scholarship from the French Society of Dermatology. K.F. is supported by an Australian National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1154805). The study was funded by the Australian NHMRC Project Grant (APP1098804). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report of this study.