Journal article

Healthy Life-Year Costs of Treatment Speed From Arrival to Endovascular Thrombectomy in Patients With Ischemic Stroke A Meta-analysis of Individual Patient Data From 7 Randomized Clinical Trials

Mohammed A Almekhlafi, Mayank Goyal, Diederik WJ Dippel, Charles BLM Majoie, Bruce CV Campbell, Keith W Muir, Andrew M Demchuk, Serge Bracard, Francis Guillemin, Tudor G Jovin, Peter Mitchell, Philip White, Michael D Hill, Scott Brown, Jeffrey L Saver

JAMA Neurology | AMER MEDICAL ASSOC | Published : 2021

Abstract

Importance: The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known. Objective: To assess the lifetime outcomes associated with speed of endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion (LVO). Data Sources: PubMed was searched for randomized clinical trials of stent retriever thrombectomy devices vs medical therapy in patients with anterior circulation LVO within 12 hours of last known well time, and for which a peer-reviewed, complete primary results article was published by August 1, 2020. Study Selection: All randomized cli..

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Grants

Funding Acknowledgements

Medtronic provided an unrestricted grant to the University of Calgary HERMES Coordinating Center for this study.