Journal article

Frequency Shift Surface-Enhanced Raman Spectroscopy Sensing: An Ultrasensitive Multiplex Assay for Biomarkers in Human Health

Wenfeng Zhu, James Andell Hutchison, Mingdong Dong, Min Li

ACS SENSORS | AMER CHEMICAL SOC | Published : 2021

Abstract

The sensitive and selective detection of biomarkers for human health remains one of the grand challenges of the analytical sciences. Compared to established methods (colorimetric, (chemi) luminescent), surface-enhanced Raman spectroscopy (SERS) is an emerging alternative with enormous potential for ultrasensitive biological detection. Indeed even attomolar (10-18 M) detection limits are possible for SERS due to an orders-of-magnitude boosting of Raman signals at the surface of metallic nanostructures by surface plasmons. However, challenges remain for SERS assays of large biomolecules, as the largest enhancements require the biomarker to enter a "hot spot" nanogap between metal nanostructure..

View full abstract

University of Melbourne Researchers

Grants

Awarded by National Natural Science Foundation of China


Awarded by Australian Government through the Australian Research Council Future Fellowship scheme


Awarded by Australian Government through the Australian Research Council Centre of Excellence in Exciton Science


Funding Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 22074147). J.A.H. acknowledges the Australian Government for funding through the Australian Research Council Future Fellowship scheme (FT180100295) and the Centre of Excellence in Exciton Science (CE170100026).