Journal article

Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Qing-zhang Tuo, Shu-ting Zhang, Peng Lei

MEDICINAL RESEARCH REVIEWS | WILEY | Published : 2021

Abstract

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is among the most frequent causes of disability and death worldwide. Current treatment approaches involve achieving rapid reperfusion either pharmacologically or surgically, both of which are time-sensitive; moreover, blood flow recanalization often causes ischemia/reperfusion injury. However, even though neuroprotective intervention is urgently needed in the event of stroke, the exact mechanisms of neuronal death during ischemic stroke are still unclear, and consequently, the capacity for drug development has remained limited. Multiple cell death pathways are implicated in the pathogenesis of ischemic stro..

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Grants

Awarded by Ministry of Science and Technology of the People's Republic of China


Awarded by China Postdoctoral Science Foundation


Awarded by National Natural Science Foundation of China


Awarded by Post Doctor Research Program of West China Hospital, Sichuan University


Awarded by National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University


Funding Acknowledgements

Ministry of Science and Technology of the People's Republic of China, Grant/Award Number: 2018YFC1312300; China Postdoctoral Science Foundation, Grant/Award Numbers: 2017M623041, 2019T120848; National Natural Science Foundation of China, Grant/Award Numbers: 81722016, 81801182, 82071191; Post Doctor Research Program of West China Hospital, Sichuan University, Grant/Award Number: 2018HXBH044; National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Grant/Award Number: Z2018B03