Change in ejection fraction and long-term mortality in adults referred for echocardiography
Geoff Strange, David Playford, Gregory M Scalia, David S Celermajer, David Prior, Jim Codde, Yih-Kai Chan, Max K Bulsara, Simon Stewart
EUROPEAN JOURNAL OF HEART FAILURE | WILEY | Published : 2021
AIMS: We investigated long-term mortality associated with changes in left ventricular ejection fraction (LVEF) in a large, real-world patient cohort. METHODS AND RESULTS: A total of 117 275 adults (63 ± 16 years, 46% women) had LVEF quantified by the same method ≥6 months apart. This included 17 343 cases (66 ± 15 years, 48% women) being initially investigated for heart failure (HF). During 3.3 [interquartile range (IQR) 1.7-6.0] years from first to last echocardiogram, median change in LVEF was -1 (IQR -8 to +5) units from a baseline of 62% (IQR 54-69%). During subsequent 7.6 (IQR 4.3-10.1) years of follow-up, 11 397 (9.7%) and 34 101 (29.1%) cases died from cardiovascular disease and all c..View full abstract
Awarded by NHMRC of Australia
This work was partially supported by Novartis Pharmaceuticals. S.S. is supported by the NHMRC of Australia (GNT1135894).