Journal article

Early metabolic acidosis in critically ill patients: a binational multicentre study

Katsunori Mochizuki, Tomoko Fujii, Eldho Paul, Matthew Anstey, David Pilcher, Rinaldo Bellomo

CRITICAL CARE AND RESUSCITATION | AUSTRALASIAN MED PUBL CO LTD | Published : 2021

Abstract

Objective: We aimed to measure the incidence, prevalence, characteristics and outcomes of intensive care unit (ICU) patients with early (first 24 hours) metabolic acidosis (MA) according to two different levels of severity with a focus on recent data. Design: We retrospectively applied two diagnostic criteria to our analysis based on literature for early MA: i) severe MA criteria (pH  7.20 and PaCO2  45 mmHg and HCO3  20 mmol/L with total Sequential Organ Failure Assessment [SOFA] score  4 or lactate  2 mmol/L), and ii) moderate MA criteria (pH < 7.30 and base excess < 4 mmol/L and PaCO2  45 mmHg). Setting: ICUs in the Australian and New Zealand Intensive Care Society Adult Patient ..

View full abstract

University of Melbourne Researchers