The effect of vitamin D supplementation on circulating osteoprogenitor cells: A pilot randomized controlled trial
Jack Feehan, Elizabeth Degabrielle, Nicholas Tripodi, Ahmed Al Saedi, Sara Vogrin, Gustavo Duque
EXPERIMENTAL GERONTOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021
Circulating osteoprogenitor (COP) cells are a relatively newly discovered mesenchymal precursors population in the peripheral blood. While some aspects of their physiology have been documented in vitro, little is known about their behavior in vivo. To facilitate understanding regarding their potential role in the management of musculoskeletal disease, more research into how these cells respond to growth factors and hormones in vivo is still required. To this end, we performed a randomized controlled pilot study investigating the effect of vitamin D supplementation on COP cells in healthy older adults. Twenty-two individuals were recruited and stratified through their baseline vitamin D level..View full abstract
Role of the funding source This study was funded by the Australian Institute for Musculoskeletal Science (AIMSS) . The funding body had no role in the design, execution, analysis or reporting of the study.