Journal article

TCR- or Cytokine-Activated CD8 Mucosal-Associated Invariant T Cells Are Rapid Polyfunctional Effectors That Can Coordinate Immune Responses.

Rajesh Lamichhane, Marion Schneider, Sara M de la Harpe, Thomas WR Harrop, Rachel F Hannaway, Peter K Dearden, Joanna R Kirman, Joel DA Tyndall, Andrea J Vernall, James E Ussher

Cell Rep | Published : 2019

Abstract

Mucosal-associated invariant T (MAIT) cells can be activated via either their T cell receptor (TCR), which recognizes MR1-bound pyrimidines derived from microbial riboflavin biosynthesis, or via cytokines. These two modes of activation may act in concert or independently, depending upon the stimulus. It is unknown, however, how MAIT cell responses differ with the mode of activation. Here, we define transcriptional and effector responses of human CD8+ MAIT cells to TCR and cytokine stimulation. We report that MAIT cells rapidly respond to TCR stimulation, producing multiple cytokines and chemokines, altering their cytotoxic granule content and transcription factor expression, and upregulating..

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