Journal article

Global impact of heparin on gene expression profiles in neural cells infected by enterovirus 71.

Hamid Reza Pourianfar, Enzo Palombo, Lara Grollo

Intervirology | Published : 2014

Abstract

OBJECTIVES: Heparan sulphate mimetics, particularly heparin (Hep), have previously been shown to considerably inhibit infection of enterovirus 71 (EV71) in Vero cells. Therefore, in this study, a genome-wide DNA microarray was performed to gain insight into the mechanism(s) of action of Hep against infection of a human neural cell line, SK-N-SH, with a clinical strain of EV71. METHODS: This study focused on a selection of EV71-induced genes whose expression profiling was exclusively affected by the antiviral activity of Hep. The selection procedure was performed through a statistical multi-level comparison with the following controls: negative control cells, compound control (cells treated w..

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University of Melbourne Researchers