Journal article

A case of ANCA-associated vasculitis presenting de novo in pregnancy, successfully treated with rituximab.

A Pefanis, DS Williams, H Skrzypek, A Fung, K Paizis

Obstetric Medicine | SAGE Publications | Published : 2020


Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are rare small vessel vasculitides of unknown cause. The pathogenic role of MPO-ANCA in the vasculitides has been supported using various animal models, with B-cells playing a role in the disease pathogenesis. Pregnancy in the presence of an autoimmune disease such as vasculitis is often associated with significant morbidity. Little is known about the outcomes when women present with de novo vasculitis during pregnancy, and the appropriate management of such presentations is unclear. We describe a case of a 33-year-old female presenting in her second pregnancy with new onset ANCA vasculitis at 12 weeks' gestation. She was succe..

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