Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study.
ME Murphy, GH Wills, S Murthy, C Louw, ALC Bateson, RD Hunt, TD McHugh, AJ Nunn, SK Meredith, CM Mendel, M Spigelman, AM Crook, SH Gillespie, undefined REMoxTB consortium
BMC Med | Published : 2018
BACKGROUND: In the REMoxTB study of 4-month treatment-shortening regimens containing moxifloxacin compared to the standard 6-month regimen for tuberculosis, the proportion of unfavourable outcomes for women was similar in all study arms, but men had more frequent unfavourable outcomes (bacteriologically or clinically defined failure or relapse within 18 months after randomisation) on the shortened moxifloxacin-containing regimens. The reason for this gender disparity in treatment outcome is poorly understood. METHODS: The gender differences in baseline variables were calculated, as was time to smear and culture conversion and Kaplan-Meier plots were constructed. In post hoc exploratory analy..View full abstract