Journal article

Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

SE Murthy, F Chatterjee, A Crook, R Dawson, C Mendel, ME Murphy, SR Murray, AJ Nunn, PPJ Phillips, Kasha P Singh, TD McHugh, SH Gillespie, undefined REMoxTB Consortium

BMC Med | Published : 2018

Abstract

BACKGROUND: Chest radiographs are used for diagnosis and severity assessment in tuberculosis (TB). The extent of disease as determined by smear grade and cavitation as a binary measure can predict 2-month smear results, but little has been done to determine whether radiological severity reflects the bacterial burden at diagnosis. METHODS: Pre-treatment chest x-rays from 1837 participants with smear-positive pulmonary TB enrolled into the REMoxTB trial (Gillespie et al., N Engl J Med 371:1577-87, 2014) were retrospectively reviewed. Two clinicians blinded to clinical details using the Ralph scoring system performed separate readings. An independent reader reviewed discrepant results for quali..

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University of Melbourne Researchers