Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.
SE Murthy, F Chatterjee, A Crook, R Dawson, C Mendel, ME Murphy, SR Murray, AJ Nunn, PPJ Phillips, Kasha P Singh, TD McHugh, SH Gillespie, undefined REMoxTB Consortium
BMC Med | Published : 2018
BACKGROUND: Chest radiographs are used for diagnosis and severity assessment in tuberculosis (TB). The extent of disease as determined by smear grade and cavitation as a binary measure can predict 2-month smear results, but little has been done to determine whether radiological severity reflects the bacterial burden at diagnosis. METHODS: Pre-treatment chest x-rays from 1837 participants with smear-positive pulmonary TB enrolled into the REMoxTB trial (Gillespie et al., N Engl J Med 371:1577-87, 2014) were retrospectively reviewed. Two clinicians blinded to clinical details using the Ralph scoring system performed separate readings. An independent reader reviewed discrepant results for quali..View full abstract
Awarded by NIAID NIH HHS
Awarded by Medical Research Council
Awarded by Bill & Melinda Gates Foundation