Journal article
Common virulence gene expression in adult first-time infected malaria patients and severe cases
JS Wichers, G Tonkin-Hill, T Thye, R Krumkamp, B Kreuels, J Strauss, HV Thien, JAM Scholz, HS Hansson, RW Jensen, L Turner, FR Lorenz, A Schöllhorn, I Bruchhaus, E Tannich, R Fendel, TD Otto, T Lavstsen, TW Gilberger, MF Duffy Show all
Elife | Published : 2021
DOI: 10.7554/ELIFE.69040
Open access
Abstract
Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis. PfEMP1 proteins have diversified and expanded to encompass many sequence variants, conferring each parasite a similar array of human endothelial receptor-binding phenotypes. Here, we analyzed RNA-seq profiles of parasites isolated from 32 P. falciparum-infected adult travellers returning to Germany. Patients were categorized into either malaria naive (n = 15) or pre-exposed (n = 17), and into severe (n = 8) or non-severe (n = 24) cases. For dif..
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Awarded by Wellcome Trust
Funding Acknowledgements
Deutsche Forschungsgemeinschaft BA 5213/3-1 Jan Stephan Wichers Anna Bachmann Danish Council for Independent Research 9039-00285B Rasmus Weisel Jensen Louise Turner Thomas Lavstsen Deutsches Zentrum fur Infektionsforschung TTU Malaria Ralf Krumkamp Egbert Tannich Rolf Fendel Anna Bachmann DESY PIF-2018-87 Jan Strauss Tim Wolf Gilberger Universitat Hamburg Judith Anna Marie Scholz National Health and Medical Research Council Michael Duffy Kirsten og Freddy Johansens Fond Rasmus Weisel Jensen Louise Turner Thomas Lavstsen Lundbeckfonden R344-2020-934 Rasmus Weisel Jensen Louise Turner Thomas Lavstsen Wellcome Trust 104111/Z/14/ZR Thomas D Otto The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.