Journal article

Common virulence gene expression in adult first-time infected malaria patients and severe cases

J Stephan Wichers, Gerry Tonkin-Hill, Thorsten Thye, Ralf Krumkamp, Benno Kreuels, Jan Strauss, Heidrun von Thien, Judith AM Scholz, Helle Smedegaard Hansson, Rasmus Weisel Jensen, Louise Turner, Freia-Raphaella Lorenz, Anna Schollhorn, Iris Bruchhaus, Egbert Tannich, Rolf Fendel, Thomas D Otto, Thomas Lavstsen, Tim W Gilberger, Michael F Duffy Show all

ELIFE | ELIFE SCIENCES PUBLICATIONS LTD | Published : 2021

Abstract

Sequestration of Plasmodium falciparum(P. falciparum)-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 (PfEMP1) adhesion proteins is central to the development of malaria pathogenesis. PfEMP1 proteins have diversified and expanded to encompass many sequence variants, conferring each parasite a similar array of human endothelial receptor-binding phenotypes. Here, we analyzed RNA-seq profiles of parasites isolated from 32 P. falciparum-infected adult travellers returning to Germany. Patients were categorized into either malaria naive (n = 15) or pre-exposed (n = 17), and into severe (n = 8) or non-severe (n = 24) cases. For dif..

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University of Melbourne Researchers

Grants

Awarded by Deutsche Forschungsgemeinschaft


Awarded by Danish Council for Independent Research


Awarded by DESY


Awarded by Lundbeckfonden


Awarded by Wellcome Trust


Funding Acknowledgements

Deutsche Forschungsgemeinschaft BA 5213/3-1 Jan Stephan Wichers Anna BachmannDanish Council for Independent Research 9039-00285B Rasmus Weisel Jensen Louise Turner Thomas LavstsenDeutsches Zentrum fur Infektionsforschung TTU Malaria Ralf Krumkamp Egbert Tannich Rolf Fendel Anna BachmannDESY PIF-2018-87 Jan Strauss Tim Wolf GilbergerUniversitat Hamburg Judith Anna Marie ScholzNational Health and Medical Research Council Michael DuffyKirsten og Freddy Johansens Fond Rasmus Weisel Jensen Louise Turner Thomas LavstsenLundbeckfonden R344-2020-934 Rasmus Weisel Jensen Louise Turner Thomas LavstsenWellcome Trust 104111/Z/14/ZR Thomas D OttoThe funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.