Nebulizer calibration using lithium chloride: an accurate, reproducible and user-friendly method.
RJ Ward, DW Reid, RF Leonard, DP Johns, EH Walters
Eur Respir J | European Respiratory Society (ERS) | Published : 1998
Conventional gravimetric (weight loss) calibration of jet nebulizers overestimates their aerosol output by up to 80% due to unaccounted evaporative loss. We examined two methods of measuring true aerosol output from jet nebulizers. A new adaptation of a widely available clinical assay for lithium (determined by flame photometry, LiCl method) was compared to an existing electrochemical method based on fluoride detection (NaF method). The agreement between the two methods and the repeatability of each method were examined. Ten Mefar jet nebulizers were studied using a Mefar MK3 inhalation dosimeter. There was no significant difference between the two methods (p=0.76) with mean aerosol output o..View full abstract