Modelling the Effect of MUC1 on Influenza Virus Infection Kinetics and Macrophage Dynamics
Ke Li, Pengxing Cao, James M McCaw
VIRUSES-BASEL | MDPI | Published : 2021
MUC1 belongs to the family of cell surface (cs-) mucins. Experimental evidence indicates that its presence reduces in vivo influenza viral infection severity. However, the mechanisms by which MUC1 influences viral dynamics and the host immune response are not yet well understood, limiting our ability to predict the efficacy of potential treatments that target MUC1. To address this limitation, we use available in vivo kinetic data for both virus and macrophage populations in wildtype and MUC1 knockout mice. We apply two mathematical models of within-host influenza dynamics to this data. The models differ in how they categorise the mechanisms of viral control. Both models provide evidence that..View full abstract
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Awarded by Australian Research Council (ARC)
Awarded by National Health and Medical Research Council (NHMRC)
Ke Li is supported by a Melbourne Research Scholarship. This work was supported by an Australian Research Council (ARC) Discovery Project (DP170103076) and a National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy (1078068).