Journal article

Glutathione S-Transferase Gene Associations and Gene-Environment Interactions for Asthma

Xin Dai, Dinh S Bui, Caroline Lodge

CURRENT ALLERGY AND ASTHMA REPORTS | CURRENT MEDICINE GROUP | Published : 2021

Abstract

PURPOSE OF REVIEW: Asthma is one of the most common chronic inflammatory airway diseases. Airway oxidative stress is defined as an imbalance between oxidative and antioxidative processes in the airways. There is evidence that chronic damage caused by oxidative stress may be involved in asthmatic inflammation and reduced lung function. Given their biological antioxidant function, the antioxidant genes in the glutathione S-transferase (GST) family are believed to be associated with development and progression of asthma. This review aims to summarize evidence on the relationship between GST gene polymorphisms and asthma and interactions with environmental exposures. RECENT FINDINGS: The current..

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Grants

Funding Acknowledgements

Dr. Dai has no personal funding relationship to declare. Dr. Caroline Lodge is funded by a Melbourne University Developing Research Momentum (DRM) grant; Dr. Dinh Bui is funded by Centre for Air pollution, energy and health Research (CAR), Australia.