Journal article

Hierarchical semantic composition of biosimulation models using bond graphs.

Niloofar Shahidi, Michael Pan, Soroush Safaei, Kenneth Tran, Edmund J Crampin, David P Nickerson

PLOS Computational Biology | Public Library of Science (PLoS) | Published : 2021


Simulating complex biological and physiological systems and predicting their behaviours under different conditions remains challenging. Breaking systems into smaller and more manageable modules can address this challenge, assisting both model development and simulation. Nevertheless, existing computational models in biology and physiology are often not modular and therefore difficult to assemble into larger models. Even when this is possible, the resulting model may not be useful due to inconsistencies either with the laws of physics or the physiological behaviour of the system. Here, we propose a general methodology for composing models, combining the energy-based bond graph approach with s..

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University of Melbourne Researchers


Awarded by NIBIB NIH HHS