Journal article
Wave reflections in the umbilical artery measured by Doppler ultrasound as a novel predictor of placental pathology
LS Cahill, G Stortz, A Ravi Chandran, N Milligan, S Shinar, CL Whitehead, SR Hobson, V Ayyathurai, A Rahman, R Saghian, KJ Jobst, C McShane, D Block-Abraham, V Seravalli, M Laurie, S Millard, C Delp, D Wolfson, AA Baschat, KE Murphy Show all
Ebiomedicine | ELSEVIER | Published : 2021
Abstract
Background: The umbilical artery (UA) Doppler pulsatility index is used clinically to detect elevated feto-placental vascular resistance. However, this metric is confounded by variation in fetal cardiac function and is only moderately predictive of placental pathology. Our group developed a novel ultrasound methodology that measures wave reflections in the UA, thereby isolating a component of the Doppler signal that is specific to the placenta. The present study examined whether wave reflections in the UA are predictive of placental vascular pathology. Methods: Standard clinical Doppler ultrasound of the UAs was performed in 241 pregnant women. Of these, 40 women met narrowly defined preset ..
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Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Acknowledgements
This work was supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of Health Grant 1U01HD087177-01 and the Canadian Institutes of Health Research Grant PJT153202.