Journal article

Amphiphilic Core Cross-Linked Star Polymers for the Delivery of Hydrophilic Drugs from Hydrophobic Matrices

Katarzyna Somszor, Stephanie Allison-Logan, Fatemeh Karimi, Thomas McKenzie, Qiang Fu, Andrea O'Connor, Greg Qiao, Daniel Heath

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2021

Abstract

The delivery of hydrophilic drugs from hydrophobic polymers is a long-standing challenge in the biomaterials field due to the limited solubility of the therapeutic agent within the polymer matrix. In this work, we develop a drug delivery mechanism that enables the impregnation and subsequent elution of hydrophilic drugs from a hydrophobic polymer material. This was achieved by synthesizing core cross-linked star polymer amphiphiles with hydrophilic cores and hydrophobic coronas. While significant work has been done to create nanocarriers for hydrophilic drugs, this work is distinct from previous work in that it designs amphiphilic and core cross-linked particles for controlled release from h..

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Grants

Awarded by Australian Research Council (ARC Future Fellowship)


Awarded by Industrial Transformation Training Centre in Additive Biomanufacturing


Funding Acknowledgements

K.S. gratefully acknowledges the support of the University of Melbourne and an Australian Government Research Training Program Scholarship (Melbourne International Research Scholarship). F.K. is a recipient of the International Postgraduate Research Scholarship. This work was funded in part by the Australian Research Council (ARC Future Fellowship FT190100280 and the Industrial Transformation Training Centre in Additive Biomanufacturing IC160100026). The authors also thank the Materials Characterization and Fabrication Platform (the University of Melbourne) for access to infrastructure and equipment.