Dendritic Cells: Neglected Modulators of Peripheral Immune Responses and Neuroinflammation in Mood Disorders?
Rafael Leite Dantas, Jana Freff, Oliver Ambree, Eva C Beins, Andreas J Forstner, Udo Dannlowski, Bernhard T Baune, Stefanie Scheu, Judith Alferink
Cells | MDPI | Published : 2021
Affective disorders (AD) including major depressive disorder (MDD) and bipolar disorder (BD) are common mood disorders associated with increased disability and poor health outcomes. Altered immune responses characterized by increased serum levels of pro-inflammatory cytokines and neuroinflammation are common findings in patients with AD and in corresponding animal models. Dendritic cells (DCs) represent a heterogeneous population of myeloid cells that orchestrate innate and adaptive immune responses and self-tolerance. Upon sensing exogenous and endogenous danger signals, mature DCs secrete proinflammatory factors, acquire migratory and antigen presenting capacities and thus contribute to ne..View full abstract
Awarded by DFG Cells in Motion Cluster of Excellence, Munster, Germany
Awarded by DFG
Awarded by German Research Foundation
The work of J.A. has been funded by the DFG EXC 1003, Grant FF-2014-01 Cells in Motion Cluster of Excellence, Munster, Germany, and by the DFG FOR2107 AL1145/5-2; SS was supported by the German Research Foundation (DFG-270650915/GRK2158 and SCHE692/6-1) and by the Manchot Graduate Schools 'Molecules of Infection III' 'Molecules of Infection IV'.