Acute stress reveals different impacts in male and female Zdhhc7-deficient mice
Nicole Kerkenberg, Christa Hohoff, Mingyue Zhang, Ilona Lang, Christiane Schettler, Evgeni Ponimaskin, Lydia Wachsmuth, Cornelius Faber, Bernhard T Baune, Weiqi Zhang
Brain Structure and Function | SPRINGER HEIDELBERG | Published : 2021
Numerous processes of neuronal development and synaptic plasticity in the brain rely on the palmitoyl acyltransferase ZDHHC7, as it palmitoylates various synaptic and extrasynaptic proteins such as neural cell adhesion molecule (NCAM) or gamma-aminobutyric acid (GABAA) receptors. In addition, ZDHHC7 palmitoylates sex steroid hormone receptors and is, therefore, indirectly linked to mental disorders that often occur because of or in conjunction with stress. In this work, we investigated how ZDHHC7 affects stress responses in mice. For this purpose, genetically modified mice with a knockout of the Zdhhc7 gene (KO) and wild-type (WT) littermates of both sexes were exposed to acute stressors or ..View full abstract
Awarded by Interdisciplinary Centre for Clinical Research (IZKF) of the University of Munster Medical School
Awarded by Deutsche Forschungsgemeinschaft (DFG)
Open Access funding enabled and organized by Projekt DEAL. This study was funded by the Interdisciplinary Centre for Clinical Research (IZKF) of the University of Munster Medical School (Zha3-005-14 and core unit PIX) and by the Deutsche Forschungsgemeinschaft (DFG Grant ZH 34/3-1 to W.Z.). It was further supported by the Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience of the University of Munster.