Impact of prior vaccination on antibody response and influenza-like illness among Australian healthcare workers after influenza vaccination in 2016
Vivian KY Leung, Annette Fox, Louise A Carolan, Malet Aban, Karen L Laurie, Julian Druce, Yi-Mo Deng, Monica A Slavin, Caroline Marshall, Sheena G Sullivan
Vaccine | ELSEVIER SCI LTD | Published : 2021
BACKGROUND: Epidemiological studies suggest that influenza vaccine effectiveness decreases with repeated administration. We examined antibody responses to influenza vaccination among healthcare workers (HCWs) by prior vaccination history and determined the incidence of influenza infection. METHODS: HCWs were vaccinated with the 2016 Southern Hemisphere quadrivalent influenza vaccine. Serum samples were collected pre-vaccination, 21-28 days and 7 months post-vaccination. Influenza antibody titres were measured at each time-point using the haemagglutination inhibition (HI) assay. Immunogenicity was compared by prior vaccination history. RESULTS: A total of 157 HCWs completed the study. The maj..View full abstract
Awarded by Melbourne Health Grant in Aid
This study was funded by the Melbourne Health Grant in Aid (Grant number GIA-002-2016). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is funded by the Australian Government Department of Health. The funding bodies were not involved in the collection, analysis, and interpretation of data, the writing of the article, or the decision to submit it for publication.