Journal article

Characterization of brain-derived extracellular vesicle lipids in Alzheimer's disease

Huaqi Su, Yepy H Rustam, Colin L Masters, Enes Makalic, Catriona A McLean, Andrew F Hill, Kevin J Barnham, Gavin E Reid, Laura J Vella

JOURNAL OF EXTRACELLULAR VESICLES | WILEY | Published : 2021

Abstract

Lipid dyshomeostasis is associated with the most common form of dementia, Alzheimer's disease (AD). Substantial progress has been made in identifying positron emission tomography and cerebrospinal fluid biomarkers for AD, but they have limited use as front-line diagnostic tools. Extracellular vesicles (EVs) are released by all cells and contain a subset of their parental cell composition, including lipids. EVs are released from the brain into the periphery, providing a potential source of tissue and disease specific lipid biomarkers. However, the EV lipidome of the central nervous system is currently unknown and the potential of brain-derived EVs (BDEVs) to inform on lipid dyshomeostasis in ..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Australian Research Council


Awarded by Alzheimer's Association


Funding Acknowledgements

AustralianNationalHealth andMedical Research Council, Grant/AwardNumbers: GNT1041413, GNT1002349, 628946; Australian ResearchCouncil, Grant/AwardNumber: LE160100015; BethlehemGriffithsResearch Foundation; Alzheimer's AustraliaDementiaResearch Foundation John Shutes ProjectGrant; Alzheimer'sAssociation, Grant/AwardNumber: AARF-18-566256