Journal article
Evaluation of 6 Commercial SARS-CoV-2 Serology Assays Detecting Different Antibodies for Clinical Testing and Serosurveillance
S Nicholson, T Karapanagiotidis, A Khvorov, C Douros, F Mordant, K Bond, J Druce, DA Williamson, D Purcell, SR Lewin, S Sullivan, K Subbarao, M Catton
Open Forum Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2021
DOI: 10.1093/ofid/ofab239
Abstract
Background: Serological testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) complements nucleic acid tests for patient diagnosis and enables monitoring of population susceptibility to inform the coronavirus disease 2019 (COVID-19) pandemic response. It is important to understand the reliability of assays with different antigen or antibody targets to detect humoral immunity after SARS-CoV-2 infection and to understand how antibody (Ab) binding assays compare to those detecting neutralizing antibody (nAb), particularly as we move into the era of vaccines. Methods: We evaluated the performance of 6 commercially available enzyme-linked immunosorbent assays (ELISAs), includin..
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Funding Acknowledgements
This work was supported by the Victorian Department of Health and Human Services and by the Australian Government Department of Health.