Journal article

Selective constraint acting on TLR2 and TLR4 genes of Japanese Rana frogs

Quintin Lau, Takeshi Igawa, Tiffany A Kosch, Yoko Satta

PeerJ | PEERJ INC | Published : 2018


Toll-like receptors (TLRs) are an important component of innate immunity, the first line of pathogen defence. One of the major roles of TLRs includes recognition of pathogen-associated molecular patterns. Amphibians are currently facing population declines and even extinction due to chytridiomycosis caused by the Batrachochytrium dendrobatidis (Bd) fungus. Evidence from other vertebrates shows that TLR2 and TLR4 are involved in innate immunity against various fungi. Such genes therefore may play a functional role in amphibian-chytridiomycosis dynamics. Frogs from East Asia appear to be tolerant to Bd, so we examined the genetic diversity that underlies TLR2 and TLR4 from three Japanese Ranid..

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University of Melbourne Researchers


Awarded by Japan Society for the Promotion of Science (JSPS)

Funding Acknowledgements

This work was supported by the Japan Society for the Promotion of Science (JSPS), including Grants-in-Aid for Scientific Research (KAKENHI) 17K15053. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.