Selective constraint acting on TLR2 and TLR4 genes of Japanese Rana frogs
Quintin Lau, Takeshi Igawa, Tiffany A Kosch, Yoko Satta
PeerJ | PEERJ INC | Published : 2018
Toll-like receptors (TLRs) are an important component of innate immunity, the first line of pathogen defence. One of the major roles of TLRs includes recognition of pathogen-associated molecular patterns. Amphibians are currently facing population declines and even extinction due to chytridiomycosis caused by the Batrachochytrium dendrobatidis (Bd) fungus. Evidence from other vertebrates shows that TLR2 and TLR4 are involved in innate immunity against various fungi. Such genes therefore may play a functional role in amphibian-chytridiomycosis dynamics. Frogs from East Asia appear to be tolerant to Bd, so we examined the genetic diversity that underlies TLR2 and TLR4 from three Japanese Ranid..View full abstract
Awarded by Japan Society for the Promotion of Science (JSPS)
This work was supported by the Japan Society for the Promotion of Science (JSPS), including Grants-in-Aid for Scientific Research (KAKENHI) 17K15053. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.