Journal article

Major histocompatibility complex selection dynamics in pathogen-infected tungara frog (Physalaemus pustulosus) populations

Tiffany A Kosch, Arnaud Bataille, Chelsea Didinger, John A Eimes, Sofia Rodriguez-Brenes, Michael J Ryan, Bruce Waldman

Biology Letters | ROYAL SOC | Published : 2016


Pathogen-driven selection can favour major histocompatibility complex (MHC) alleles that confer immunological resistance to specific diseases. However, strong directional selection should deplete genetic variation necessary for robust immune function in the absence of balancing selection or challenges presented by other pathogens. We examined selection dynamics at one MHC class II (MHC-II) locus across Panamanian populations of the túngara frog, Physalaemus pustulosus, infected by the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd). We compared MHC-II diversity in highland túngara frog populations, where amphibian communities have experienced declines owing to Bd, with those in ..

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University of Melbourne Researchers


Awarded by National Research Foundation of Korea - government of the Republic of Korea (MOE)

Awarded by National Scientific Foundation

Funding Acknowledgements

The research was supported by the National Research Foundation of Korea, funded by the government of the Republic of Korea (MOE; grant no. 2015R1D1A1A01057282 to B.W.), and the National Scientific Foundation (grant no. IBN 0517328 to M.J.R.).