Journal article

Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle-Immune Cell Interactions in Human Blood

Jiaying Song, Yi Ju, Thakshila H Amarasena, Zhixing Lin, Srinivas Mettu, Jiajing Zhou, Md Arifur Rahim, Ching-Seng Ang, Christina Cortez-Jugo, Stephen J Kent, Frank Caruso

ACS NANO | AMER CHEMICAL SOC | Published : 2021

Abstract

Poly(ethylene glycol) (PEG) is widely used in particle assembly to impart biocompatibility and stealth-like properties in vivo for diverse biomedical applications. Previous studies have examined the effect of PEG molecular weight and PEG coating density on the biological fate of various particles; however, there are few studies that detail the fundamental role of PEG molecular architecture in particle engineering and bio-nano interactions. Herein, we engineered PEG particles using a mesoporous silica (MS) templating method and investigated how the PEG building block architecture impacted the physicochemical properties (e.g., surface chemistry and mechanical characteristics) of the PEG partic..

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Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by National Health and Medical Research Council Senior Principal Research Fellowships


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). F.C. and S.J.K. acknowledge the awards of National Health and Medical Research Council Senior Principal Research Fellowships (GNT1135806 and GNT1136322, respectively). This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) and the Biosciences Microscopy Facility at The University of Melbourne, the Victorian Node of the Australian National Fabrication Facility (ANFF), and the Peter Doherty Institute. We acknowledge Y. Qu and Y. Han for assistance with experiments and H. G. Kelly and M. Faria for helpful discussions.