Astrocyte and glutamate involvement in the pathogenesis of epilepsy in Alzheimer's disease
Hattapark Dejakaisaya, Patrick Kwan, Nigel C Jones
EPILEPSIA | WILEY | Published : 2021
Alzheimer's disease (AD) can increase the risk of epilepsy by up to 10-fold compared to healthy age-matched controls. However, the pathological mechanisms that underlie this increased risk are poorly understood. Because disruption in brain glutamate homeostasis has been implicated in both AD and epilepsy, this might play a mechanistic role in the pathogenesis of epilepsy in AD. Prior to the formation of amyloid beta (Aβ) plaques, the brain can undergo pathological changes as a result of increased production of amyloid precursor protein (APP) and Aβ oligomers. Impairments in the glutamate uptake ability of astrocytes due to astrogliosis are hypothesized to be an early event occurring before A..View full abstract
PK is supported by a Medical Research Future Fund Fellowship; HD is supported by The Scholarship in Commemoration of HM King Bhumibol Adulyadej 90th Birthday Anniversary.