Journal article

DNA methylation signal has a major role in the response of human breast cancer cells to the microenvironment

P Mathot, M Grandin, G Devailly, F Souaze, V Cahais, S Moran, M Campone, Z Herceg, M Esteller, P Juin, P Mehlen, R Dante

Oncogenesis | NATURE PUBLISHING GROUP | Published : 2017


Breast cancer-associated fibroblasts (CAFs) have a crucial role in tumor initiation, metastasis and therapeutic resistance by secreting various growth factors, cytokines, protease and extracellular matrix components. Soluble factors secreted by CAFs are involved in many pathways including inflammation, metabolism, proliferation and epigenetic modulation, suggesting that CAF-dependent reprograming of cancer cells affects a large set of genes. This paracrine signaling has an important role in tumor progression, thus deciphering some of these processes could lead to relevant discoveries with subsequent clinical implications. Here, we investigated the mechanisms underlying the changes in gene ex..

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University of Melbourne Researchers


Awarded by Ligue Contre le Cancer

Awarded by Institut National Du Cancer

Awarded by European Research Council

Funding Acknowledgements

We thank Dr Frederique Souaze for primary culture of breast CAF and helpful discussions. We are grateful to Dr B Manship for editing of this manuscript and helpful discussions. PM and GD are recipients of the fellowship from the Ligue Nationale contre le Cancer. MG is a recipient of the fellowship from the Fondation ARC pour la Recherche sur le Cancer and LabExDEVwe-CAN. We acknowledge Integragen for library preparations and highthrouput sequencing experiments The present work was supported by Ligue Contre le Cancer (EL2015.LNCC), Institut National Du Cancer (2011-143 and 2016-166), European Research Council (294079), Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, University of Lyon, and Centre Leon Berard.