Journal article

Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells.

Jingjing Pei, Jieru Deng, Zuodong Ye, Jiaying Wang, Hongchao Gou, Wenjun Liu, Mingqiu Zhao, Ming Liao, Lin Yi, Jinding Chen

Autophagy | Published : 2016

Abstract

A growing number of studies have demonstrated that both macroautophagy/autophagy and apoptosis are important inner mechanisms of cell to maintain homeostasis and participate in the host response to pathogens. We have previously reported that a functional autophagy pathway is trigged by infection of classical swine fever virus (CSFV) and is required for viral replication and release in host cells. However, the interplay of autophagy and apoptosis in CSFV-infected cells has not been clarified. In the present study, we demonstrated that autophagy induction with rapamycin facilitates cellular proliferation after CSFV infection, and that autophagy inhibition by knockdown of essential autophagic p..

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University of Melbourne Researchers