Thesis / Dissertation

The relationship between disease status and acoustic analysis of speech in Multiple Sclerosis

Gustavo Noffs, Adam Vogel (ed.)

Published : 2021

Abstract

Multiple Sclerosis (MS) is a common cause of disability in young adults. Modern MS treatment has markedly improved long-term outcomes for the most common type of MS, i.e., relapsing-remitting MS. However, optimal pharmacological treatment decisions depend on early detection of disease progression. Validated assessment of progression includes disability scales and standard structural magnetic resonance imaging (MRI) of the brain (brain volume changes), but these are not sensitive to the early disability worsening. More dynamic tools are required to increase the responsiveness of MS monitoring. Objective speech analysis offers several potential advantages for disease monitoring, including shor..

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