Thesis / Dissertation

Virus-induced Glucocorticoid Insensitivity in the Airways

Asmaa Radwan Ahmed Elsayed, Alastair Stewart (ed.)

Published : 2020

Abstract

Chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD) pose a major public health burden. Hospitalization, mortality and increased health care costs owing to these diseases are amongst the consequences of exacerbations. Exacerbations are usually elicited by respiratory infections, allergens, environmental pollutants or occupational sensitizers. These factors may work in either an additive or synergistic manner. Regular management using inhaled glucocorticoids (GCs) has an unquestioned benefit in alleviating exacerbations unless the respiratory viruses were the trigger. Due to the few alternative anti-inflammatory therapies available, restoring glucocorti..

View full abstract