Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner
A Zhuang, AC Calkin, S Lau, H Kiriazis, DG Donner, Y Liu, ST Bond, SC Moody, EAM Gould, TD Colgan, SR Carmona, M Inouye, TQ de Aguiar Vallim, EJ Tarling, GA Quaife-Ryan, JE Hudson, ER Porrello, P Gregorevic, XM Gao, XJ Du Show all
iScience | Elsevier BV | Published : 2021
Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including the heart. The lncRNA OIP5-AS1 (1700020I14Rik/Cyrano) has been studied in several settings; however its role in cardiac pathologies remains mostly uncharacterized. Using a series of in vitro and ex vivo methods, we demonstrate that OIP5-AS1 is regulated during cardiac development in rodent and human models and in disease settings in mice. Using CRISPR, we engineered a global OIP5-AS1 knockout (KO) mouse and demonstrated that female KO mice develop exacerbated heart failure following cardiac press..View full abstract
Related Projects (1)
USING GENE DELIVERY TECHNOLOGIES TO DEFINE NOVEL MECHANISMS OF SKELETAL MUSCLE ADAPTATION, AND DEVELOP MUSCLE-DIRECTED INTERVENTIONS FOR FRAILTY AND SERIOUS ILLNESS
The focus of my research is to investigate the cellular mechanisms underlying regulation of skeletal muscle size and function in health and ..