Journal article

Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner

A Zhuang, AC Calkin, S Lau, H Kiriazis, DG Donner, Y Liu, ST Bond, SC Moody, EAM Gould, TD Colgan, SR Carmona, M Inouye, TQ de Aguiar Vallim, EJ Tarling, GA Quaife-Ryan, JE Hudson, ER Porrello, P Gregorevic, XM Gao, XJ Du Show all

iScience | Elsevier BV | Published : 2021

Abstract

Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including the heart. The lncRNA OIP5-AS1 (1700020I14Rik/Cyrano) has been studied in several settings; however its role in cardiac pathologies remains mostly uncharacterized. Using a series of in vitro and ex vivo methods, we demonstrate that OIP5-AS1 is regulated during cardiac development in rodent and human models and in disease settings in mice. Using CRISPR, we engineered a global OIP5-AS1 knockout (KO) mouse and demonstrated that female KO mice develop exacerbated heart failure following cardiac press..

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