Efficacy and Safety of Traditional Chinese Herbal Medicine for Antipsychotic-Related Constipation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Wen-Wang Rao, Juan-Juan Yang, Han Qi, Sha Sha, Wei Zheng, Ling Zhang, Gabor S Ungvari, Chee H Ng, Yu-Tao Xiang
FRONTIERS IN PSYCHIATRY | FRONTIERS MEDIA SA | Published : 2021
Background: Constipation is a common but often ignored side effect of antipsychotic treatment, although it is associated with adverse outcomes. The results of the efficacy and safety of traditional Chinese herbal medicine (TCM) in treating constipation are mixed across studies. This is a systematic review and meta-analysis of randomized controlled trials (RCTs) of the efficacy and safety of TCM compared to Western medicine (WM) in treating antipsychotic-related constipation. Methods: Major international electronic (PubMed, EMBASE, Cochrane Library, and Web of Science) and Chinese (Wanfang, WeiPu VIP, SinoMed, and CNKI) databases were searched from their inception to November 29, 2020. Meta-a..View full abstract
Awarded by National Science and Technology Major Project for investigational new drug
Awarded by Beijing Municipal Science and Technology Commission
Awarded by University of Macau
This study was supported by the National Science and Technology Major Project for investigational new drug (2018ZX09201-014), the Beijing Municipal Science and Technology Commission (No. Z181100001518005), and the University of Macau (MYRG2019-00066-FHS).