Journal article

Sleep architectural dysfunction and undiagnosed obstructive sleep apnea after chronic ischemic stroke

Elie Gottlieb, Mohamed S Khlif, Laura Bird, Emilio Werden, Thomas Churchward, Matthew P Pase, Natalia Egorova, Mark E Howard, Amy Brodtmann

SLEEP MEDICINE | ELSEVIER | Published : 2021

Abstract

OBJECTIVE/BACKGROUND: Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It remains unclear whether sleep disturbances are transient post-stroke or are potentially enduring sequelae in chronic stroke. Here, we characterize sleep architectural dysfunction, sleep-respiratory parameters, and hemispheric sleep in ischemic stroke patients in the chronic recovery phase compared to healthy controls. PATIENTS/METHODS: Radiologically confirmed ischemic stroke patients (n = 28) and matched control participants (n = 16) were tested with ambulatory polysomnography, bi-hemispheric sleep EEG, and demographic, stroke-severity, mood, and sleep-circadian qu..

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Grants

Awarded by National Heart Foundation


Awarded by National Health and Medical Research Council


Awarded by National Institute on Aging


Awarded by Alzheimer's Association


Awarded by Australian Research Council


Awarded by Heart Foundation Future Leader Fellowship


Funding Acknowledgements

M.P.P. is funded by a National Heart Foundation to Australia Future Leader Fellowship (102052), with funding for sleep research from the National Health and Medical Research Council (GTN1158384), National Institute on Aging (1R01AG062531-01A1), and Alzheimer's Association (2018-AARG-591358). N.E. is supported by Australian Research Council (DE180100893). A.B. is funded by a Heart Foundation Future Leader Fellowship (100784) and by the National Health and Medical Research Council (GTN1094974, GTN1020526).